Author

Michael Hultström

Uppsala UniversityORCID 0000-0003-4675-1099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:differential expression· 2 Research Focus:GWAS / association mapping· 2 Assay:proteomics· 2 Assay:whole-exome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Guillaume Butler‐LaporteiD· 4 shared John Brent RichardsiD· 4 shared Hugo ZebergiD· 3 shared Miklós LipcseyiD· 3 shared Robert FrithiofiD· 3 shared Sirui ZhouiD· 3 shared Tomoko NakanishiiD· 3 shared Vincenzo ForgettaiD· 3 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersGenetic & Genomic Medicine

Guillaume Butler‐LaporteORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

Satoshi Yoshiji, Guillaume Butler‐Laporte, Tianyuan Lu, Julian Willett, Chen‐Yang Su, Tomoko Nakanishi, David Morrison, Yiheng Chen, Kevin Y. H. Liang, Michael Hultström, Yann Ilboudo, Zaman Afrasiabi, Shanshan Lan, Naomi Duggan, Chantal DeLuca, , John Brent Richards

The paper identifies nephronectin as a mediator of obesity's effect on COVID-19 severity using proteome-wide Mendelian randomization and validates its expression in lung cells.

Nature Metabolism · Feb 20, 2023Peer-reviewedGenetic & Genomic Medicine

HLA allele-calling using whole-exome sequencing identifies 129 novel associations in 11 autoimmune diseases: a multi-ancestry analysis in the UK Biobank

Guillaume Butler‐Laporte, Yossi Farjoun, Tomoko Nakanishi, Tianyuan Lu, Erik Abner, Yiheng Chen, Michael Hultström, Andres Metspalu, Lili A. Milani, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Satoshi Yoshiji, Yann Ilboudo, Kevin Y. H. Liang, , John Brent Richards

This study uses whole-exome sequencing to directly call HLA alleles in the UK Biobank, identifying 129 novel associations between HLA alleles and 11 autoimmune diseases.

medRxiv · Jan 15, 2023 · PreprintGenetic & Genomic Medicine

Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

Bożena Bruhn‐Olszewska, Hanna Davies, Daniil Sarkisyan, Ulana Juhas, Edyta Rychlicka-Buniowska, Magdalena Wójcik, Monika Horbacz, Marcin Jąkalski, Paweł Olszewski, Jakub Orzechowski Westholm, Agata Smialowska, Karol Wierzba, Åsa Torinsson Naluai, Niklas Jern, Lars‐Magnus Andersson, , Jan Piotr Dumanski

The paper investigates LOY in leukocytes as a risk factor for severe COVID-19 in men, finding higher LOY levels in critical cases and associations with immune-related outcomes.

Genome Medicine · Dec 13, 2022Peer-reviewedGenetic & Genomic Medicine

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro, Sergio Daga, Francesca Fava, Elisa Benetti, Sara Amitrano, Mirella Bruttini, Maria Palmieri, Susanna Croci, Mirjam Lista, Giada Beligni, Floriana Valentino, Ilaria Meloni, , Pier Giorgio Scotton

The paper develops a machine learning model to predict COVID-19 severity using exonic variants from whole exome sequencing data, finding that variants across all frequency categories contribute to severity.

Human Genetics · Dec 10, 2021Peer-reviewedGenetic & Genomic Medicine

A Neanderthal OAS1 Isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies

Sirui Zhou, Guillaume Butler‐Laporte, Tomoko Nakanishi, David Morrison, Jonathan Afilalo, Marc Afilalo, Laetitia Laurent, Maik Pietzner, Nicola D. Kerrison, Kaiqiong Zhao, Elsa Brunet‐Ratnasingham, Danielle Henry, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, , John Brent Richards

This study identifies OAS1 as a protective factor against COVID-19 severity and susceptibility using Mendelian randomization and case-control analyses.

Nature Medicine · Feb 25, 2021Peer-reviewedGenetic & Genomic Medicine