Author

José V.V. Isola

Oklahoma Medical Research FoundationORCID 0000-0002-3168-3188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1

Frequent Co-Authors

Michael B. StoutiD· 2 shared Alexei ChemiakineiD· 1 shared Aubrey ConverseiD· 1 shared Binyam MogessieiD· 1 shared Blake WiedenheftiD· 1 shared Cecilia Soledad BlenginiiD· 1 shared Chen JiniD· 1 shared Devanshi JainiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Michael B. StoutORCID

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2 papers

Recent·Most cited

Cell BiologyPLoS BiologyPeer-reviewedJun 23, 2025

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

Aubrey Converse, Madeline J. Perry, Shweta S. Dipali…·Francesca E. Duncan

This study identifies multinucleated giant cells (MNGCs) in aging ovaries, showing their unique immune and degradation-related molecular signatures through transcriptomic and imaging analyses.

38 citationstop 1%

mousenon-human primate

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GeneticsNature AgingPeer-reviewedApr 22, 2025

Two retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity

Thomas W.P. Wood, William S. Henriques, Harrison B. Cullen…·Luke Edwin Berchowitz

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

5 citations

mousehuman

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