Francesca E. Duncan

Matched Plasma and Tissue Proteomics Reveal the Selective Nature of Circulating Biomarkers of Human Aging

This study identifies that plasma proteins selectively reflect tissue-specific aging processes in muscle and ovary, revealing context-dependent age-related changes.

The human ovary exhibits dynamic molecular remodeling in the decades post-menopause

This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

Age-dependent dysregulated post-ovulatory debris clearance promotes ovarian fibroinflammation

This study shows that impaired post-ovulatory debris clearance in aged ovaries leads to persistent corpus luteum accumulation and fibroinflammation.

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

The paper integrates multimodal techniques to show ovarian fibrosis is a measurable and targetable feature of human reproductive aging.

Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism

This study identifies PCSK5A and GDF9 as key regulators of cumulus-oocyte-complex matrix integrity and cumulus cell migration during late ovulation, with implications for fertility therapeutics.

Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C

The paper develops MEIOSA to test biocompatibility of 3D-printed resins using oocytes and finds Parylene-C coating prevents toxicity in all tested resins.

Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary.

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

Inorganic profiles of preimplantation embryos and the association of zinc with Nanog expression in the blastocyst

The paper profiles inorganic elements in mouse embryos and shows zinc supplementation during blastocyst formation increases Nanog expression in the inner cell mass.

Self-organizing ovarian somatic organoids preserve cellular heterogeneity and reveal cellular contributions to ovarian aging

This study develops ovarian somatic organoids that maintain cellular diversity and reveal age-related changes in cellular composition and function.

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.

A complex phenotypic assay of mammalian oocyte maturation identifies compounds that block meiotic progression for non-hormonal contraceptive discovery

This study screens compounds to identify those that block meiotic progression in mouse oocytes, offering potential non-hormonal contraceptive candidates.

The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review

This systematic review summarizes evidence on heat stress's adverse effects on mammalian oocytes and ovaries, highlighting impaired function and reduced quality.

Single-cell and spatiotemporal profile of ovulation in the mouse ovary

This study maps the spatiotemporal profile of ovulation in mice using single-cell RNA-seq and spatial transcriptomics, identifying cell state markers and interactions involved in the process.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

This study identifies multinucleated giant cells (MNGCs) in aging ovaries, showing their unique immune and degradation-related molecular signatures through transcriptomic and imaging analyses.

A single-cell atlas inclusive of age-related menopause reveals global tissue and ovarian remodeling

The paper presents MenoMap, a single-cell atlas of 2 million cells from 13 tissues including the ovary, analyzing gene expression changes across pre- and post-menopausal donors.

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

The paper establishes a senotype of doxorubicin-induced senescence in postmenopausal human ovarian tissue using single nuclei sequencing and proteomics.

Transcriptomic analysis of whole staged ovarian follicles reveals stage-specific folliculogenesis signatures in mice

This study uses single follicle RNA-seq to identify transcriptional signatures of ovarian follicles in mice, revealing stage-specific gene pathways involved in folliculogenesis.

Regulation of Female Reproductive Aging by the Spag17 Gene

This study identifies Spag17 as a key modulator of female reproductive aging, showing its role in maintaining fertility and preventing age-related complications.

Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse

This study shows that systemic Pirfenidone treatment reduces ovarian fibrosis and improves ovarian function in aged mice by modulating the fibro-inflammatory microenvironment.

The oocyte microenvironment is altered in adolescents compared to oocyte donors.

This study compares the molecular signatures of cumulus cells and follicular fluid between adolescents and oocyte donors, finding significant differences in gene expression and cytokine profiles.

CD38 regulates ovarian function and fecundity via NAD+ metabolism

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.