This study shows that age-related changes in cohesion strength in oocytes lead to different types of chromosome segregation errors in eggs from young and old females.

bioRxiv · May 11, 2026 · PreprintCell Biology

The cytoplasmic lattice in mammalian eggs sequesters ubiquitination machinery and tubulin in reserve

Yujie Li, Wan Zheng, Jiyeon Leem, Chunxiang Wu, Shaogeng Tang, Binyam Mogessie, Yong Xiong

This study reveals the structure and function of the cytoplasmic lattice in mammalian eggs, showing it sequesters ubiquitination machinery and tubulin for use during early embryonic development.

bioRxiv · Apr 1, 2026 · PreprintBiophysics

Two retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity

Thomas W.P. Wood, William S. Henriques, Harrison B. Cullen, Mayra Romero, Cecilia Soledad Blengini, Shreya N. Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Xifan Wang, Raphaëlle Laureau, Alexei Chemiakine, Rishad C. Khondker, José V.V. Isola, , Luke Edwin Berchowitz

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

Nature Aging · Apr 22, 2025Peer-reviewedGenetics

A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.

Jiyeon Leem, Tom Lemonnier, Ani Khutsaidze, Lei Tian, Xiaojun Xing, Suxia Bai, Timothy Nottoli, Binyam Mogessie

bioRxiv · Feb 27, 2025 · PreprintCell Biology