Michael B. Stout

Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipocyte Progenitor Self-Renewal and Adipogenic Differentiation

This study shows tamoxifen reduces subcutaneous adipocyte progenitor self-renewal and adipogenesis by suppressing Wisp2, linking endocrine therapy to metabolic risks like T2D.

A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging.

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

Tamoxifen transiently disrupts estrous cyclicity without altering long-term ovarian aging trajectories

This study shows that tamoxifen temporarily disrupts estrous cycles but does not alter long-term ovarian aging patterns or transcriptional outcomes.

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

The paper integrates multimodal techniques to show ovarian fibrosis is a measurable and targetable feature of human reproductive aging.

Development and Function of Ovarian Lymphatic Vasculature

This study investigates the development and function of the ovarian lymphatic vasculature in mice, revealing its origin and the role of VEGF-C/VEGFR-3 signaling in preventing fibrosis and ovarian aging.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

This study identifies multinucleated giant cells (MNGCs) in aging ovaries, showing their unique immune and degradation-related molecular signatures through transcriptomic and imaging analyses.

Two retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake

This study finds that aged mice acquire intravenous opioid self-administration faster than young mice, with variable effects on intake and cue-responding for remifentanil but not fentanyl.

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

This study shows metformin induces different mitochondrial remodeling in rat skeletal muscle based on baseline aerobic capacity and muscle type.

Consistent specificity and efficiency of tamoxifen-mediated cre induction across ages

The paper compares tamoxifen-mediated cre induction efficiency and specificity in young and old mice, finding no significant difference in microglial labeling or translatomic changes.

Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans

The paper identifies microglia as the primary source of MHC-I in mice and humans, showing age-related and Alzheimer's-associated increases in MHC-I expression and related receptors.

Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sex

The paper investigates how chromosomal content and gonadal sex influence gene expression and DNA modification patterns in mouse hippocampi, revealing sex chromosome-specific regulatory effects.

Litter expansion alters metabolic homeostasis in a sexually divergent manner

This study shows that litter expansion in mice leads to long-term metabolic changes that are sex-dependent, with males showing more pronounced effects than females.

Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia

The paper introduces a NuTRAP method to isolate RNA and DNA from specific CNS cell types, revealing cell type-specific epigenetic and transcriptomic differences in microglia and astrocytes.