Path of differentiation defines human macrophage identity
Katie Frenis, Brianna Badalamenti, Ohanez Mamigonian, Chen Weng, Dahai Wang, Sara Fierstein, Parker Côté, Hesper Khong, Hojun Li, Edroaldo Lummertz da Rocha, Vijay G. Sankaran, R. Grant Rowe
This study identifies two distinct macrophage differentiation pathways in humans, showing how developmental origin influences macrophage function and identifies a method to expand tissue-resident macrophages.
bioRxiv · Jan 24, 2025 · PreprintMolecular Biology