R. Grant Rowe

This paper identifies small-molecule modulators that enhance the generation of functional cytotoxic T cells from hiPSCs, increasing CTL production up to 2000-fold.

The paper identifies positive feedback loops between Lin28-RBPs and mRNAs that regulate spatiotemporal transitions of progenitors during organogenesis.

This study identifies ELOVL2 as a key lipid metabolism enzyme that regulates B cell progenitor development and immune aging in mice and humans.

This study identifies two distinct macrophage differentiation pathways in humans, showing how developmental origin influences macrophage function and identifies a method to expand tissue-resident macrophages.

This study identifies Erg as a master transcription factor whose upregulation during aging is critical for adult hematopoietic stem cell function and resistance to leukemogenesis.

The paper identifies downregulation of the CCR1 immune pathway in SF3B1-mutated cancers and links it to potential therapeutic targets.

The paper identifies a Lin28b-let-7-PRC1 axis that regulates hematopoietic maturation across development, with Cbx2 playing a key role in controlling developmental timing of hematopoietic transcription factors.

The paper uses single cell RNA-seq to study human hematopoietic stem and progenitor cells (HSPCs) across development and aging, revealing age-related transcriptional changes and differentiation trajectories.