Author

Manish Chandra Choudhary

Brigham and Women's HospitalORCID 0000-0002-3192-7840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Jonathan Z. LiiD· 3 shared Amy K. BarczakiD· 2 shared Gregory E. EdelsteiniD· 2 shared Jacob E. LemieuxiD· 2 shared Jeffrey A. SparksiD· 2 shared Julie BoucauiD· 2 shared Karry Su· 2 shared Mamadou Barry· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Jonathan Z. LiORCID

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3 papers

Recent·Most cited

Post-infection immune response in adults with COVID-19 with and without nirmatrelvir-ritonavir treatment and virologic rebound

Dibya Ghimire, Chloe M. Hasund, John Bianchi Colangeli, May Yee Liew, Emory Abar, Mamadou Barry, Andrew Alexandrescu, Benjamin L. Kotzen, Zahra Reynolds, Eliza Passell, Chase B. Mandell, Zoie Smith-Sparks, Karry Su, Julie Boucau, Owen T. Glover, , Jacob E. Lemieux

This study examines immune responses in adults with COVID-19 who received or did not receive nirmatrelvir-ritonavir, finding no differences in immune markers between those with and without virologic rebound.

bioRxiv · Jun 23, 2026 · PreprintImmunology

Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance

Tin Phan, Ruy Miguel Ribeiro, Gregory E. Edelstein, Julie Boucau, Rockib Uddin, Caitlin Marino, May Y. Liew, Mamadou Barry, Manish Chandra Choudhary, Dessie Tien, Karry Su, Zahra Reynolds, Yijia Li, Shruti Sagar, Tammy D. Vyas, , Alan S. Perelson

The paper models viral rebound after nirmatrelvir-ritonavir treatment, finding that target cell preservation and incomplete viral clearance drive rebound, with extended treatment reducing this risk.

Journal of Virology · Feb 4, 2025Peer-reviewedImmunology

Two mutations in the SARS-CoV-2 spike protein and RNA polymerase complex are associated with COVID-19 mortality risk

Georg Hahn, Chloe M. Wu, Sanghun Lee, Julian Hecker, Sharon Marie Lutz, Sebastien Haneuse, Dandi Qiao, Dawn Lisa DeMeo, Manish Chandra Choudhary, Behzad Etemad, Abbas Mohammadi, Elmira Esmaeilzadeh, Michael H. Cho, Rudolph E. Tanzi, Jonathan Z. Li, , Christoph Lange

The paper identifies two SARS-CoV-2 genome loci associated with increased COVID-19 mortality risk using logistic regression on whole-genome sequencing data.

bioRxiv · Nov 17, 2020 · PreprintGenomics