Meghan R. Riddell

Advanced Maternal Age Impairs Decidual Angiogenesis and Spiral Artery Remodelling

This study shows that advanced maternal age impairs decidual angiogenesis and spiral artery remodeling in mice, contributing to pregnancy complications and cardiovascular risk.

aPKC-ζ III promotes trophoblast fusion by altering Par-3 interactions with Hippo Signaling Kinase LATS1

This study identifies aPKC-ζ III as a regulator of trophoblast fusion by modulating Hippo signaling through its interaction with Par-3 and LATS1.

Placental cytotrophoblast microvillar stabilization is required for cell-cell fusion

The paper identifies microvillar stabilization via ezrin as essential for cytotrophoblast fusion and differentiation in the placenta.

Loss of polarity regulators initiates gasdermin E mediated pyroptosis in human maternal fetal interface trophoblasts

The paper shows that loss of aPKC activity in trophoblasts leads to gasdermin E-mediated pyroptosis, linking polarity regulators to inflammation in the maternal-fetal interface.