Author

Amy L. Brightwell

University of Calgary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ashley ZubkowskiiD· 1 shared Jasmine NguyeniD· 1 shared Jennifer Anne ThompsoniD· 1 shared Jessica L. WageriD· 1 shared Katrina M. Melan· 1 shared Khushali PateliD· 1 shared Larissa Baker· 1 shared Meghan R. RiddelliD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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1 shared paperDevelopmental Biology

Ashley ZubkowskiORCID

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2 papers

Recent·Most cited

High Maternal Adiposity During Pregnancy Programs an Imbalance in the Lipidome and Predisposes to Diet-induced Hepatosteatosis in the Offspring

Taylor B. Scheidl, Jessica L. Wager, Larissa Baker, Amy L. Brightwell, Katrina M. Melan, Sebastian Larion, Ousseynou Sarr, Timothy R.H. Regnault, Stefan J. Urbanski, Jennifer Anne Thompson

This study shows that high maternal adiposity during pregnancy increases offspring susceptibility to diet-induced hepatosteatosis, with lipidomic changes linked to intrauterine environment effects.

Bioscience Reports · Sep 14, 2023Peer-reviewedDevelopmental Biology

Loss of polarity regulators initiates gasdermin E mediated pyroptosis in human maternal fetal interface trophoblasts

Khushali Patel, Jasmine Nguyen, Sumaiyah Z. Shaha, Amy L. Brightwell, Wendy K. Duan, Ashley Zubkowski, Meghan R. Riddell

The paper shows that loss of aPKC activity in trophoblasts leads to gasdermin E-mediated pyroptosis, linking polarity regulators to inflammation in the maternal-fetal interface.

bioRxiv · Jun 30, 2022 · PreprintDevelopmental Biology