Benjamin Martin

Core passive and facultative mTOR-mediated mechanisms coordinate mammalian protein synthesis and decay

The paper investigates how protein synthesis and decay rates are coordinated in mammalian cells, revealing passive and mTOR-dependent mechanisms that maintain proteome stability.

RealTrace: Uncovering biological dynamics hidden under measurement noise in time-lapse microscopy data

RealTrace is a Bayesian method that removes measurement noise from time-lapse microscopy data to reveal biological dynamics, showing fluctuating growth rates and gene expression in single cells.

Flux analysis reveals specific regulatory modalities of gene expression

The paper uses flux analysis to quantify gene expression dynamics in mouse bone marrow-derived DCs, revealing six regulatory modalities and highlighting protein degradation's role in LPS response.

RNA degradation heavily impacts mRNA co-expression

The paper shows that mRNA degradation, not just regulatory mechanisms, drives co-expression correlations in single-cell RNA sequencing data.

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

The paper shows TASOR interacts with CNOT1 and other RNA degradation factors to repress HIV expression by promoting RNA degradation and H3K9me3 deposition.

Discovery of a Cellular Mechanism Regulating Transcriptional Noise

The paper identifies DNA base-excision repair as a mechanism that amplifies transcriptional noise, enhancing cellular plasticity and reprogramming efficiency.

Discovery and Engineering of a Therapeutic Interfering Particle (TIP): a combination self-renewing antiviral

This paper discovers and engineers an HIV-1 Therapeutic Interfering Particle (TIP) that suppresses viral replication and protects CD4+ T cells in humanized mice.