Thomas Harrison Barker

This paper develops a multiscale computational model to study how Thy-1 expression in fibroblast subpopulations influences fibrotic foci formation in IPF.

The paper investigates how impaired mechanoperception in lung fibroblasts affects gene expression programs, revealing a link between integrin signaling and HOXA5 silencing in lung development and regeneration.

The paper uses a multiscale computational model to predict how environmental changes and drug treatments affect microvascular remodeling in idiopathic pulmonary fibrosis.

This study shows B-1 cells and IgMOSE reduce lung fibrosis by modulating CXCR4 and Id3, with sIgM-/- mice showing increased mortality from bleomycin injury.