Author

Sean J. Williams

Tufts UniversityORCID 0000-0002-3221-3102Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

James A. Van DeventeriD· 2 shared Arlinda Rezhdo· 1 shared Manjie HuangiD· 1 shared Nikhil U. NairiD· 1 shared Rebecca L. Hershman· 1 shared Vikas D. TrivediiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersSynthetic Biology

James A. Van DeventerORCID

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2 papers

Recent·Most cited

Pharmacophore-driven antibody discovery on the yeast surface

Manjie Huang, Sean J. Williams, Vikas D. Trivedi, Nikhil U. Nair, James A. Van Deventer

This paper describes a method to discover protein-small molecule hybrids using pharmacophore-driven antibody discovery on yeast, showing that screening outcomes are pharmacophore-dependent.

bioRxiv · Oct 16, 2025 · PreprintSynthetic Biology

Design, Construction, and Validation of a Yeast-Displayed Chemically Expanded Antibody Library

Arlinda Rezhdo, Rebecca L. Hershman, Sean J. Williams, James A. Van Deventer

This paper describes a yeast-displayed chemically expanded antibody library and demonstrates its use in identifying function-disrupting antibodies through initial screening.

ACS Synthetic Biology · Mar 18, 2025Peer-reviewedSynthetic Biology