James A. Van Deventer

This paper develops molecular probes to manipulate specific subpopulations in microbial communities using bacteriocins and validates them in synthetic populations.

This paper describes a method to discover protein-small molecule hybrids using pharmacophore-driven antibody discovery on yeast, showing that screening outcomes are pharmacophore-dependent.

This study screens eukaryotic release factor 1 variants in yeast to enhance noncanonical amino acid incorporation, identifying mutations that improve efficiency and showing complementary effects with other genetic code expansion strategies.

This study presents a strategy using OrthoRep to evolve aminoacyl-tRNA synthetases in yeast, resulting in efficient incorporation of non-canonical amino acids into proteins.

This paper describes a yeast-displayed chemically expanded antibody library and demonstrates its use in identifying function-disrupting antibodies through initial screening.

This paper demonstrates the incorporation of two noncanonical amino acids into yeast proteins, enabling chemoselective modification at two distinct sites for applications in biology and drug discovery.

The paper identifies yeast gene knockouts that enhance noncanonical amino acid incorporation efficiency at amber stop codons using a pooled knockout screen and FACS.

The paper evaluates yeast-bacterial cell-cell interactions using flow cytometry and FACS to characterize nanobody-antigen binding.

This paper reports the discovery of new aminoacyl-tRNA synthetase variants in yeast for genetic code expansion, doubling the number of available translationally active aaRSs.

This paper demonstrates that the Methanomethylophilus alvus PylRS and its tRNA can incorporate noncanonical amino acids into yeast proteins, expanding the toolkit for genetic encoding in yeast.

The paper introduces single plasmid systems for genetic code expansion in yeast and shows they are as effective as dual plasmid systems for noncanonical amino acid incorporation.

This paper evaluates how different reporter systems affect measurements of noncanonical amino acid incorporation in yeast, finding that dual-fluorescent protein reporters provide consistent and precise quantification.