Amyloid Beta Oligomers Accelerate ATP-Dependent Phase Separation of Ago2 to RNA Processing Bodies
Sritama Ray, Sumangal Roychowdhury, Yogaditya Chakrabarty, Saikat Banerjee, Krishnananda Chattopadhyay, Kamalika Mukherjee, Suvendra N. Bhattacharyya
This study shows amyloid beta oligomers enhance Ago2 phase separation to RNA processing bodies by promoting miRNA-mRNA targeting, while HuR counteracts this effect.
bioRxiv · Mar 14, 2024 · PreprintNeuroscience