Souvik Ghosh

This study examines how 3D extracellular matrix scaffolds affect the transcriptome of hepatoma cells, aiming to understand their growth and differentiation potential in 3D cultures.

The paper shows that GW182 proteins restrict the export of used miRNAs via extracellular vesicles in cancer cells, independent of HuR, and that this process is linked to miRNA turnover and cellular senescence.

The paper investigates how mitochondrial dysfunction affects miRNA trafficking and export by altering eIF4E compartmentalization and mTORC1 activity in mammalian cells.

The paper develops PAQR and KAPAC to analyze PAS use and motif activities in RNA-seq data, identifying Polypyrimidine tract binding protein 1 as a regulator of PAS choice in glioblastoma.

The paper uses single-cell sequencing and mathematical modeling to estimate miRNA target parameters and uncover their in vivo hierarchy.

The paper analyzes 3′ end sequencing data to identify novel polyadenylation signals and demonstrates HNRNPC's repressive role in poly(A) site usage and 3′ end processing.