Susanta Chatterjee

This study shows that GIGYF2/4EHP-mediated translational repression helps maintain cellular homeostasis after ionizing radiation by preserving proteostasis and cell viability.

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

The paper shows that specific miRNAs, including miR-122, are reversibly shuttled to mitochondria in stressed hepatic cells, where they regulate apoptosis-related gene expression and cytosolic miRNA levels.

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

The paper identifies primary miRNAs that coordinate the biogenesis of secondary miRNAs to regulate immune response in activated macrophages.

The paper shows that GW182 proteins restrict the export of used miRNAs via extracellular vesicles in cancer cells, independent of HuR, and that this process is linked to miRNA turnover and cellular senescence.

The paper investigates how mitochondrial dysfunction affects miRNA trafficking and export by altering eIF4E compartmentalization and mTORC1 activity in mammalian cells.