Author

Bruce P Graham

University of StirlingORCID 0000-0002-3243-2532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:electronic health records· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

Jim KayiD· 2 shared William A. PhillipsiD· 2 shared Amy RichardsoniD· 1 shared Conny Kopp‐ScheinpflugiD· 1 shared Ian D. ForsytheiD· 1 shared Jaan AruiD· 1 shared Jim W. Kay· 1 shared Joern R. SteinertiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersNeuroscience

Jim KayORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Control of two-pathway signal integration in a model neocortical pyramidal cell

Bruce P Graham, Jim Kay, William A. Phillips

The paper shows how neuromodulation and inhibition alter two-stream signal integration in a neocortical pyramidal cell model, affecting burst firing and information transmission.

bioRxiv · Apr 21, 2025 · PreprintNeuroscience

Context-sensitive processing in a model neocortical pyramidal cell with two sites of input integration

Bruce P Graham, Jim Kay, William A. Phillips

The paper uses simulations to analyze how different input strengths affect burst firing in a neocortical pyramidal cell and identifies four modes of information processing.

Neural Computation · Mar 3, 2025Peer-reviewedNeuroscience

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

Amy Richardson, Victoria Ciampani, Mihai Stancu, Kseniia Bondarenko, Sherylanne Newton, Joern R. Steinert, Nadia Pilati, Bruce P Graham, Conny Kopp‐Scheinpflug, Ian D. Forsythe

This study shows that Kv3.3 subunits regulate presynaptic action potential waveform and neurotransmitter release at the calyx of Held synapse, affecting high-frequency transmission.

eLife · May 5, 2022Peer-reviewedNeuroscience

Bayesian modelling of BAC firing as a mechanism for apical amplification in neocortical pyramidal neurons

Jim W. Kay, W. A. Phillips, Jaan Aru, Bruce P Graham, Matthew E. Larkum

The paper presents a Bayesian model of BAC firing in pyramidal neurons to show how apical inputs can amplify basal responses without corrupting the signal, suggesting a new framework for understanding cortical function.

bioRxiv · Jul 16, 2019 · PreprintNeuroscience

A multi-scale model reveals cellular and physiological mechanisms underlying hyperpolarisation-gated synaptic plasticity

Yubin Xie, Marcel Kazmierczyk, Bruce P Graham, Mayank B. Dutia, Melanie I. Stefan, Mayank B. Dutia

The paper presents a multi-scale computational model to explore the mechanisms of hyperpolarisation-gated synaptic plasticity in the medial vestibular nucleus.

bioRxiv · Jan 23, 2019 · PreprintNeuroscience