Sherylanne Newton

The mouse Cdh23ahl allele drives early cochlear dysfunction and phenotypic heterogeneity before progressive hearing loss

This study shows the Cdh23ahl allele causes early cochlear dysfunction and phenotypic variability in mice before progressive hearing loss, with altered mechanoelectrical transduction and transcriptional changes.

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

This study shows that Kv3.3 subunits regulate presynaptic action potential waveform and neurotransmitter release at the calyx of Held synapse, affecting high-frequency transmission.

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

This study investigates the role of Neuroplastin in mammalian hearing, showing that only the Np55 isoform is essential for cochlear hair cell function and that its absence interacts genetically with Cdh23 mutations to cause hearing loss.