Matthew E. Larkum

This study shows that activating GABAergic neurons in the superior colliculus of mice triggers a coordinated sequence of orienting movements involving multiple effectors.

The paper investigates how dendritic turnover zones in the secondary motor cortex support rule switching without expanding the cortical engram by analyzing spine dynamics and modeling synaptic reorganization.

The paper investigates memory-based and surround-based pattern completion in human V1 using fMRI, finding distinct laminar decoding profiles for each mechanism.

The paper investigates how cortical layers change during learning, finding that layer 5 and 2/3 show distinct activity patterns across different brain regions and times.

The paper examines representational drift across different cortical layers and finds distinct spatial and temporal patterns in Layer 2/3 and Layer 5.

The paper investigates the role of apical tuft dendrites in the anterolateral motor cortex in flexible learning using a rule-switching paradigm.

The paper shows that neurons in the vibrissal motor cortex (vM1) respond differently to sensory stimuli depending on the behavioral context, with context-specific recruitment of neuronal populations.

The paper investigates the structural and functional differences between shaft and spine synapses, finding that shaft synapses are less stable and more responsive to activity changes.

This study shows that mTORC1-dependent translation in layer 5b neurons is essential for memory consolidation through activity-dependent plasticity.

This study investigates how mice control individual whisker movements and facial coordination during a whisking-to-touch task, revealing stereotyped patterns and fine motor control.

The paper explores how nonlinear dendritic integration in PV+ basket cells modulates hippocampal oscillations through bimodal dendritic strategies.

This study shows binge feeding increases food intake by suppressing olfactory flavor representation in the anterior piriform cortex through specific neuronal activity patterns.

This study shows that mice do not uniformly express defensive behaviors when exposed to predators, instead showing context-dependent and variable responses.

This paper constructs a biophysical model of perceptual awareness in mice that explains neural and behavioral signatures and predicts electrophysiological responses.

This study identifies distinct roles of cortical layer 5 IT and ET neurons in associative learning using transgenic mice and calcium imaging.

This paper introduces SPARCLS, a high-speed 3D random-access scanning method achieving 340 kHz point rate, and demonstrates its application in imaging synaptic events in mammalian and zebrafish models.

This study investigates the neural mechanisms of fast versus slow decision-making in mice using a novel floating-platform system and neuroimaging, revealing distinct roles for medial and lateral frontal cortex.

The paper shows how visual cortex neurons adjust their responses to direct inputs and contextual signals through opposing plasticity mechanisms, enhancing improbable inputs or omissions.

The paper investigates input sources to layer 1 of mouse somatosensory cortex using retrograde tracing and optogenetics, revealing local and long-range contributions and their interactions.

The paper identifies two distinct neural codes, burst fraction and event rate, that convey stimulus information and error signals during learning, with burst fraction showing stronger modulation and temporal alignment with behavioral accuracy.

The paper shows that whisker asymmetry predicts turn direction in mice earlier than eye movement during navigation tasks.

This study investigates the role of Pten T366 phosphorylation in cortical connectivity and behavior, finding that its disruption leads to cognitive deficits and sensory impairments in mice.

The paper introduces a tool for simultaneous optical recording and optogenetic stimulation in two cortical layers of mice.

This study investigates how a GABAA-agonist affects spatial memory consolidation in humans, showing impaired memory-guided navigation when modulation occurs early post-learning.

The paper shows that perirhinal cortex input to neocortical layer 1 is critical for early memory formation through dendritic calcium elevation and burst firing in layer 5 pyramidal neurons.

The paper shows that whisker asymmetry in mice signals their behavioral state and motor preparation during a visual task.

The paper investigates how dendritic GABAB receptors modulate nonlinear information transfer in layer 5 pyramidal neurons by affecting dendritic and somatic compartment interactions.

The paper presents a Bayesian model of BAC firing in pyramidal neurons to show how apical inputs can amplify basal responses without corrupting the signal, suggesting a new framework for understanding cortical function.