Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
CJ San Felipe, Jyoti Batra, Monita Muralidharan, Shivali Malpotra, Durga Anand, Rachel Bauer, Kliment A. Verba, Danielle L. Swaney, Nevan J. Krogan, Michael Grabe, James S. Fraser
This study develops a biophysical model to show how lipid binding and mutations affect Orf9b's conformational equilibrium and its interaction with Tom70, influencing interferon suppression.
eLife · Aug 29, 2025Peer-reviewedBiochemistry