Author

CJ San Felipe

University of California, San FranciscoORCID 0000-0002-2695-5951Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

James S. FraseriD· 3 shared Kliment A. VerbaiD· 3 shared Nevan J. KroganiD· 3 shared Danielle L. SwaneyiD· 2 shared Durga Anand· 2 shared Jyoti BatraiD· 2 shared Michael GrabeiD· 2 shared Monita MuralidharaniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersBiophysics

James S. FraserORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 21, 2026

Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules

CJ San Felipe, Kliment A. Verba, Nevan J. Krogan…·James S. Fraser

This paper identifies two strategies to modulate the Orf9b-Tom70 interaction by screening for small molecules that either stabilize Orf9b dimer or block its binding to Tom70, with potential to restore interferon signaling against SARS-CoV-2.

DOI 10.64898/2026.04.27.721040

humanproteomics

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Systems BiologyCell Host & MicrobePeer-reviewedMay 14, 2026

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan

4 citationstop 1%

humanmouse

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BiochemistryeLifePeer-reviewedAug 29, 2025

Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

CJ San Felipe, Jyoti Batra, Monita Muralidharan…·James S. Fraser

This study develops a biophysical model to show how lipid binding and mutations affect Orf9b's conformational equilibrium and its interaction with Tom70, influencing interferon suppression.

1 citation

biophysical modelinghost-pathogen & immune response

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