Kliment A. Verba

This paper identifies two strategies to modulate the Orf9b-Tom70 interaction by screening for small molecules that either stabilize Orf9b dimer or block its binding to Tom70, with potential to restore interferon signaling against SARS-CoV-2.

This study develops small molecules that activate the tumor suppressor kinase LKB1 and shows their therapeutic benefits in cancer cell lines.

The paper presents cryo-EM structures of the PI3Kα/KRas complex on lipid bilayers, revealing the conformational changes and molecular mechanisms of PI3Kα activation.

This study develops a biophysical model to show how lipid binding and mutations affect Orf9b's conformational equilibrium and its interaction with Tom70, influencing interferon suppression.

EMSequenceFinder accurately assigns amino acid sequences to cryo-EM map backbone fragments, outperforming existing methods in resolution 3-10 Å maps.

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

This study evaluates the Gatan Alpine detector at 100-200 keV for cryo-EM, showing improved resolution and performance compared to the Gatan K3.

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

The paper investigates how GTP binding and hydrolysis control dynamic instability in PhuZ filaments, revealing structural changes and mechanisms distinct from microtubules.