Jyoti Batra

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells

This study investigates BANAL-236, a SARS-CoV-2-related bat virus, showing it can use human entry factors and evade human innate immunity, suggesting potential for zoonotic spillover.

Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling

This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.

Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

This study develops a biophysical model to show how lipid binding and mutations affect Orf9b's conformational equilibrium and its interaction with Tom70, influencing interferon suppression.

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.