Author

Masato Isono

National Center for Global Health and MedicineORCID 0000-0002-3263-0459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Fumihiko TakeuchiiD· 3 shared Norihiro KatoiD· 3 shared Ken YamamotoiD· 2 shared Kotaro Mori· 2 shared Masahiro NakatochiiD· 2 shared Mitsuhiro Yokota· 2 shared Sahoko IchiharaiD· 2 shared Tomohiro KatsuyaiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersGenetic & Genomic Medicine

Fumihiko TakeuchiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Simultaneous assessment of genetic and epigenetic contributions to plasma lipid levels with respect to cardiovascular risk

Fumihiko Takeuchi, Masaya Yamamoto, Masahiro Nakatochi, Kozue Takano, Atsuko Imai Okazaki, Sakurako Emoto, Yasuharu TABARA, Tomohiro Katsuya, Ken Yamamoto, Masato Isono, Kotaro Mori, Tatsuaki Matsubara, Sahoko Ichihara, Mitsuhiro Yokota, Hisao Hara, , Norihiro Kato

The paper develops a model to assess genetic and epigenetic contributions to plasma lipid levels and finds that combining rare variants, PRS, and MRS improves LDL-C prediction.

Journal of Atherosclerosis and Thrombosis · Feb 18, 2026Peer-reviewedGenetic & Genomic Medicine

Gene regulation modules in non-alcoholic fatty liver disease revealed by single-nucleus ATAC-seq

Fumihiko Takeuchi, Yi-Qiang Liang, Hana Shimizu-Furusawa, Masato Isono, Mia Yang Ang, Kotaro Mori, Taizo Mori, Eiji Kakazu, Sachiyo Yoshio, Norihiro Kato

This study uses single-nucleus ATAC-seq and machine learning to identify gene regulation modules and core genes in NAFLD progression in rats.

bioRxiv · Jul 12, 2022 · PreprintGenomics

Identification of type 2 diabetes loci in 433,540 East Asian individuals

Cassandra Nichole Spracklen, Momoko Horikoshi, Young Jin Kim, Kuang Lin, Fiona Bragg, Sanghoon Moon, Suzuki Ken, Claudia H.T. Tam, Yasuharu Tabara, Soo‐Heon Kwak, Fumihiko Takeuchi, Jirong Long, Victor Lim, Jin Fang Chai, Chien-Hsiun Chen, , Kyong Soo Park

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.

Nature · May 6, 2020Peer-reviewedGenetics