Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer
Jussi Nikkola, Lauri Ryyppö, Juuso Vuorinen, Lauri Moilanen, Maarit Ahtiainen, Kirsi Pylvänäinen, Hanna Selin, Tuomo Virtanen, Matti Nykter, Thea Veitonmäki, Jukka‐Pekka Mecklin, Toni T. Seppälä, Matti Annala
This study analyzes the somatic mutation landscape of Lynch syndrome-associated urothelial cancer and finds a lack of TERT promoter mutations and a distinct mutation profile.
Cell Reports · Oct 1, 2025Peer-reviewedCancer Biology