Kai Kruse

The paper shows that tissue mechanics control epithelial multilayering by regulating cell differentiation and movement strategies in the developing mouse epidermis.

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

This study uses deep learning and spatial data to show how tumor architecture and cell states co-evolve, influencing colorectal cancer outcomes.

This study identifies CerS4's role in regulating hair follicle stem cell niche formation through sphingolipid metabolism, impacting skin homeostasis and barrier function.

FAN-C simplifies Hi-C data analysis by providing a comprehensive tool with matrix generation, analysis, and visualization capabilities, compatible with common Hi-C formats.

The paper shows cohesin disrupts polycomb-dependent chromosomal interactions to regulate gene repression in embryonic stem cells.

Hi-C in 2-cell-like mouse cells ties MERVL retroelement transcription to transient insulating domain boundaries, with insertions differing between strains, placing retroelements at the origin of embryonic genome architecture.

The paper introduces Low-C, a low-input Hi-C method, demonstrating its reproducibility and application in analyzing chromatin conformation in primary B-cells from a lymphoma patient.