Toni T. Seppälä

Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer

This study analyzes the somatic mutation landscape of Lynch syndrome-associated urothelial cancer and finds a lack of TERT promoter mutations and a distinct mutation profile.

Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome

This study uses deep learning and spatial data to show how tumor architecture and cell states co-evolve, influencing colorectal cancer outcomes.

Sustained epithelial interferon signaling modulates incomplete pathologic response in colorectal cancer

This study identifies interferon signaling in epithelial cells as a factor contributing to incomplete response to chemotherapy in colorectal cancer, suggesting potential therapeutic targets.

In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency

The paper identifies geranylgeranyl diphosphate as essential for pancreatic cancer growth through in vivo CRISPR screening and shows that targeting its synthesis reduces tumor burden.

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

This study identifies retrotransposon insertions in colorectal tumors, linking them to cancer initiation and poor patient survival.