NeuroscienceScience Translational MedicinePeer-reviewed
Ectopic HCN4 expression drives mTOR-dependent epilepsy
Lawrence S. Hsieh, John H. Wen, Lena H. Nguyen…·Angélique Bordey
The paper identifies ectopic HCN4 expression in FCM neurons as a cAMP-dependent seizure mechanism in TSC and FCDII, suggesting HCN4 as a gene therapy target for epilepsy.
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