Author

Longbo Zhang

Yale UniversityORCID 0000-0002-9077-3239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Angélique BordeyiD· 2 shared Lena H. NguyeniD· 2 shared Anne E. AndersoniD· 1 shared Dennis D. SpenceriD· 1 shared Heather A. BorniD· 1 shared John H. WeniD· 1 shared Juan Torres-ReveroniD· 1 shared Lawrence S. HsiehiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Angélique BordeyORCID

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2 papers

Recent·Most cited

Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy

Lena H. Nguyen, Youfen Xu, Travorn Mahadeo, Longbo Zhang, Tiffany V. Lin, Heather A. Born, Anne E. Anderson, Angélique Bordey

This study shows that increasing 4E-BP1 activity in juvenile mice with FMCD reduces neuronal dysfunction and seizures by correcting electrophysiological and structural abnormalities.

Brain · Oct 15, 2021Peer-reviewedNeuroscience

Ectopic HCN4 expression drives mTOR-dependent epilepsy

Lawrence S. Hsieh, John H. Wen, Lena H. Nguyen, Longbo Zhang, Stephanie A. Getz, Juan Torres-Reveron, Ying Wang, Dennis D. Spencer, Angélique Bordey

The paper identifies ectopic HCN4 expression in FCM neurons as a cAMP-dependent seizure mechanism in TSC and FCDII, suggesting HCN4 as a gene therapy target for epilepsy.

Science Translational Medicine · Nov 18, 2020Peer-reviewedNeuroscience