Angélique Bordey

This study investigates how mutations in mTOR pathway genes affect cortical neuron development and function, finding shared and distinct impacts on synaptic activity.

This study shows that increasing 4E-BP1 activity in juvenile mice with FMCD reduces neuronal dysfunction and seizures by correcting electrophysiological and structural abnormalities.

The paper identifies ectopic HCN4 expression in FCM neurons as a cAMP-dependent seizure mechanism in TSC and FCDII, suggesting HCN4 as a gene therapy target for epilepsy.