Author

Heidi H. Pak

The University of Texas Southwestern Medical CenterORCID 0000-0002-3287-6133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Allison N. GrossbergiD· 1 shared Cara L. GreeniD· 1 shared Daniel ParedesiD· 1 shared Dudley W. LammingiD· 1 shared Emil SjulstokiD· 1 shared Joseph S. TakahashiiD· 1 shared Lauren PalluthiD· 1 shared Mikaela Koller· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Allison N. GrossbergORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintMar 5, 2026

Two Stages of Dynamic Metabolic and Transcriptomic Remodeling During the Adaptation to Caloric Restriction in Male C57BL/6J

Heidi H. Pak, Emil Sjulstok, Lauren Palluth, Joseph S. Takahashi

This study identifies two stages of metabolic and transcriptomic changes during caloric restriction in mice, revealing adiponectin as a key integrator of systemic adaptation.

1 citation

mousebulk RNA-seq

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PhysiologyCell ReportsPeer-reviewedAug 20, 2024

Non-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Heidi H. Pak, Allison N. Grossberg, Rachel R. Sanderfoot…·Dudley W. Lamming

This study reveals that calorie restriction's effects on metabolism and molecular processes depend on the timing of measurements relative to feeding, not just diet alone.

13 citations

mousemetabolomics

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