Distinct signaling center and progenitor identity dynamics initiate human forebrain patterning
Afnan Azizi, Dana Fakhreddine, Fursham Hamid, Zeno Messi, Stephanie Strohbuecker, François Guillemot, Corinne Houart
The paper identifies human-specific features of telencephalic patterning in early development using single-cell transcriptomics and spatial imaging, showing delayed ventral SHH signaling and enhanced anterior FGF signaling compared to mice.
bioRxiv · Mar 25, 2026 · PreprintDevelopmental Biology