François Guillemot

The paper identifies human-specific features of telencephalic patterning in early development using single-cell transcriptomics and spatial imaging, showing delayed ventral SHH signaling and enhanced anterior FGF signaling compared to mice.

This study shows that a modified Ascl1 variant, Ascl1SA6, can reprogram glial cells into interneurons that resemble canonical cortical interneurons when combined with Dlx2, improving their laminar positioning.

This study shows that ATRX mutation type affects chromatin response to retinoic acid in neuroblastoma, influencing differentiation and therapeutic response.

The paper identifies sequential transcription factor programs that govern the activation of quiescent hippocampal stem cells through single-cell transcriptomic analysis in mice.

The paper shows adult-born dentate granule neurons contribute to pattern completion, a process critical for episodic memory, with implications for mental health disorders.

This study uses FnCas9 to generate fluorescently labeled hESC lines for tracking and sorting neural lineages in 2D cultures and 3D cortical organoids.

This study defines the clinical spectrum and genotype-phenotype correlations of BCL11A-IDD by analyzing 75 patients with molecular and clinical data.

The paper identifies a proneural gene combinatorial code that diversifies neocortical neural progenitor cells through gene regulatory networks and cell fate decisions.

This study shows ASCL1 interacts with mSWI/SNF complexes to regulate chromatin structure and gene expression during human neurogenesis.

This study shows that bumetanide treatment after traumatic brain injury increases microglia-interneuron contact and improves cognitive function by altering microglial activation and BDNF expression.

This study shows that Wnt/beta-catenin signaling is not required for adult hippocampal NSC homeostasis, despite their responsiveness to the signal.

This study identifies transcriptional and chromatin changes during astrocyte maturation in vivo and in culture, showing that extrinsic signals regulate intrinsic transcription factors to drive maturation.

The paper shows that hippocampal stem cells in mice undergo progressive behavioral changes that reduce depletion and ensure lifelong neurogenesis.

The paper identifies altered nucleocytoplasmic partitioning and nuclear accumulation of polyadenylated transcripts as conserved features of quiescence in neural stem cells.

This study shows NOTCH signaling regulates early thymic epithelial progenitor cells and mTEC lineage emergence during fetal thymus development.

The paper shows Bcl6 promotes neurogenic conversion by repressing extrinsic self-renewal pathways like Wnt through transcriptional silencing.