Author

Edward N. Pugh

University of California, DavisORCID 0000-0002-3293-6538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 3 Assay:electrophysiology· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gabriel PeinadoiD· 3 shared Kaitryn E. RonningiD· 2 shared Marie E. BurnsiD· 2 shared Prescott C. AlexanderiD· 2 shared Connor E. WeissiD· 1 shared David John CalkinsiD· 1 shared Debarshi MustafiiD· 1 shared Joseph CarrolliD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

Gabriel PeinadoORCID

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Author profile →

4 papers

Recent·Most cited

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response

Connor E. Weiss, Teng Liu, Vimal Prabhu Pandiyan, Yan Cao, Debarshi Mustafi, Joseph Carroll, Kirill A. Martemyanov, Edward N. Pugh, Ramkumar Sabesan

This study uses optoretinography in R9AP-bradyopsia patients to show that G-protein signaling is essential for the human cone elongation response.

bioRxiv · May 1, 2026 · PreprintNeuroscience

Biophysical Basis of the in vivo ERG of the Mouse: Rod, RPE and Müller glial Cell Contributions To Dark and to Light-driven Changes in Sub-Retinal Space o

Gabriel Peinado, Prescott C. Alexander, Kaitryn E. Ronning, Marie E. Burns, Edward N. Pugh

The paper measures ERGs in mice to assess contributions of rod, RPE, and Müller glial cells to dark and light-driven changes in sub-retinal space ion concentrations.

bioRxiv · Nov 9, 2025 · PreprintBiophysics

Biophysical Basis of the in vivo Electroretinogram of the Mouse: Current Source Density Analysis of Genetically and Pharmacologically Isolated Rod photoreceptor-driven Currents

Gabriel Peinado, Prescott C. Alexander, Kaitryn E. Ronning, Marie E. Burns, Edward N. Pugh

The paper develops a biophysical model of rod photoreceptors in mice to analyze the electroretinogram (ERG) a-wave, confirming that extracellular capacitive current and HCN1 channel activity shape the a-wave's relaxation and plateau.

bioRxiv · Feb 5, 2025 · PreprintBiophysics

Biophysical Basis of the in vivo Electroretinogram of the Mouse: 4-Shell Current Source Density Model

Gabriel Peinado, Ratheesh Kumar, Vincent Yao, David John Calkins, Paul FitzGerald, William E. Schiesser, Edward N. Pugh

The paper develops a 4-shell current source density model to explain the biophysical basis of the in vivo electroretinogram in mice, showing it better explains ERG waveforms than the classic Rodieck-Ford model.

bioRxiv · Jan 28, 2025 · PreprintBiophysics