This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Alzheimer s & Dementia · Jul 1, 2026Peer-reviewedGenetic & Genomic Medicine

Widespread gray and white matter microstructural alterations in dual cognitive-motor impairment

Kavita Singh, Yang An, Kurt G. Schilling, Dan Benjamini

This study identifies widespread microstructural changes in gray and white matter in individuals with dual cognitive-motor impairment compared to isolated impairments and controls.

bioRxiv · Apr 18, 2025 · PreprintNeuroscience

Sex, racial, and APOE-ϵ4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

Amalia Jo Peterson, Aditi Sathe, Dimitrios Zaras, Yisu Yang, Alaina Durant, Kacie Deters, Niranjana Shashikumar, Kimberly R. Pechman, Michael E. Kim, Chenyu Gao, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Yuankai Huo, Logan C. Dumitrescu, , Derek B. Archer

The paper examines how sex, race, and APOE-ε4 allele status affect white matter microstructure across multiple aging and Alzheimer's disease cohorts.

bioRxiv · Jun 10, 2024 · PreprintNeuroscience

Neuronal microstructural changes in the human brain are associated with neurocognitive aging

Kavita Singh, Stephanie Barsoum, Kurt G. Schilling, Yang An, Luigi Ferrucci, Dan Benjamini

This study uses diffusion MRI to identify microstructural changes in the human brain associated with neurocognitive aging, finding that microstructural markers are more strongly linked to cognitive performance than macrostructural changes.

Aging Cell · Apr 24, 2024Peer-reviewedNeuroscience

Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging

Derek B. Archer, Kurt G. Schilling, Niranjana Shashikumar, Varuna H. Jasodanand, Elizabeth E. Moore, Kimberly R. Pechman, Murat Bilgel, Lori L. Beason‐Held, Yang An, Andrea T. Shafer, Luigi Ferrucci, Shannon L. Risacher, Katherine A. Gifford, Bennett A. Landman, Angela Lee Jefferson, , Alzheimer’s Disease Neuroimaging Initiative

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Sep 29, 2023Peer-reviewedNeuroscience

Novel genomic loci and pathways influence patterns of structural covariance in the human brain

Junhao Wen, Ilya M. Nasrallah, Ahmed Abdulkadir, Theodore Daniel Satterthwaite, Zhijian Yang, Güray Erus, Timothy Robert‐Fitzgerald, Ashish Singh, Aristeidis Sotiras, Aleix Boquet-Pujadas, Elizabeth Mamourian, Jimit J. Doshi, Yuhan Cui, Dhivya Srinivasan, Ioanna Skampardoni, , the ADNI studies

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

medRxiv · Jul 20, 2022 · PreprintGenetic & Genomic Medicine

Neurotransmitter imbalance in the brain and Alzheimer’s pathology

Stuart G. Snowden, Amera A. Ebshiana, Abdul Hye, Olga Pletniková, Richard O’Brien, Yang An, John Troncoso, Cristina Legido‐Quigley, Madhav Thambisetty

The paper investigates neurotransmitter imbalances in Alzheimer's disease by analyzing metabolite levels in brain regions of control, AD, and asymptomatic AD groups.

bioRxiv · Jul 15, 2018 · PreprintNeuroscience

Temporal order of Alzheimer’s disease-related cognitive marker changes in BLSA and WRAP longitudinal studies

Murat Bilgel, Rebecca L. Koscik, Yang An, Jerry L. Prince, Susan M. Resnick, Sterling C. Johnson, Bruno Jedynak

The paper uses longitudinal data to identify the temporal order of cognitive marker changes in Alzheimer’s disease, finding that digit span tests decline earliest followed by verbal memory and other tests.

Journal of Alzheimer s Disease · Jul 18, 2017Peer-reviewedNeuroscience