Cristina Legido‐Quigley

This study uses Mendelian randomisation to identify causal metabolome-wide effects on psychiatric and neurodegenerative disorders, finding 85 significant associations and shared genetic variants.

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This study performs GWAS on quantitative AD biomarkers and cognitive traits, identifying new loci associated with memory performance and cognitive decline.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

The paper identifies metabolic pathways associated with cardiovascular autonomic neuropathy in type 1 diabetes using metabolomics and lipidomics analyses.

The paper conducts GWAS on CSF Alzheimer's disease biomarkers, identifying genetic associations with NF-L, YKL-40, and Ng levels.

This study uses Mendelian Randomization to investigate causal relationships between blood metabolites and Alzheimer's Disease, identifying several metabolites as potential causal factors.

The paper conducts a genome-wide association study (GWAS) on Alzheimer’s disease CSF biomarkers in the EMIF-AD dataset, identifying novel genetic signals and confirming existing associations.

The paper integrates lipidomics and proteomics data to identify modules associated with Alzheimer's disease phenotypes and risk loci in immune and lipid pathways.

The paper introduces lipidomeR, a tool for analyzing lipidomics data, demonstrating its application in three studies to reveal lipidomic patterns across different conditions.

The paper describes the fecal metabolome in cryogenically collected samples from healthy participants, identifying metabolites and their variation across different areas of the stool.

The paper investigates neurotransmitter imbalances in Alzheimer's disease by analyzing metabolite levels in brain regions of control, AD, and asymptomatic AD groups.