This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Alzheimer s & Dementia · Jul 1, 2026Peer-reviewedGenetic & Genomic Medicine

HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization

Myo Htet, Camila Estay-Olmos, Lan Hu, Yiyang Wu, Brian E. Powers, Clorissa D. Campbell, Aishwarya Rameshwar, Mohamed Rafiuddin Ahmed, Timothy J. Hohman, Yanling Wang, Julie A. Schneider, David A. A Bennett, Vilas Menon, Philip L. De Jager, Garrett A. Kaas, , Celeste B. Greer

This study investigates the role of the HEXIM1/P-TEFb complex in regulating RNA polymerase II pause release and immediate early gene induction in neurons during depolarization.

Journal of Biological Chemistry · Feb 25, 2026Peer-reviewedNeuroscience

Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's Disease

Xavier Bledsoe, Ting‐Chen Wang, Yiyang Wu, Derek B. Archer, Hung Hsin Chen, Adam Christian Naj, William S. Bush, Timothy J. Hohman, Logan C. Dumitrescu, Jennifer Elizabeth Below, Eric R. Gamazon

The paper links PSMC3 expression to Alzheimer's Disease through neuroimaging and genetic analyses, showing its association with brain structure changes and dementia family history.

Alzheimer s & Dementia · Feb 1, 2026Peer-reviewedGenetic & Genomic Medicine

Single Cell Landscape of Sex-specific Drivers of Alzheimers Disease

Yiyang Wu, Kyle J. Travaglini, Mariano I. Gabitto, Christopher Dirk Keene, Amy R. Dunn, Catherine Cook Kaczorowski, Philip L. De Jager, Vilas Menon, Julie A. Schneider, David A. A Bennett, Logan C. Dumitrescu, Timothy J. Hohman

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedNeuroscience

Eye blinks synchronize with musical beats during music listening

Yiyang Wu, Xiangbin Teng, Yi Du

The paper shows that eye blinks synchronize with musical beats in non-musicians, linking this behavior to neural and white matter mechanisms.

PLoS Biology · Nov 18, 2025Peer-reviewedNeuroscience

The Filterprep: A Simple and Efficient Approach for High-Yield, High-Purity Plasmid DNA Purification

Yu-Hsuan Cheng, Yiyang Wu, Yung-Chun Shih, Yu-Qian Lin, Yu-Wei Chang, Yuheng Wu, En-Wei Hu, Ren-Hsuan Ku, Cheng-Mu Wu, Shao-Chi Wu, Ting-Yu Yeh, Chung-Te Chang

The paper introduces Filterprep, a method for high-yield, high-purity plasmid DNA purification that is faster, cheaper, and more transparent than commercial kits.

New Biotechnology · Sep 13, 2025Peer-reviewedBiochemistry

Eyes robustly blink to musical beats like tapping

Yiyang Wu, Xiangbin Teng, Yi Du

The paper shows that eye blinks synchronize with musical beats in non-musicians, revealing a new form of auditory-motor synchronization.

bioRxiv · Jul 4, 2024 · PreprintNeuroscience

Association of 10 VEGF Family Genes with Alzheimer's Disease Endophenotypes at Single Cell Resolution

Yiyang Wu, Julia B. Libby, Logan C. Dumitrescu, Philip L. De Jager, Vilas Menon, Julie A. Schneider, David Alan Bennett, Timothy J. Hohman

This study investigates the role of 10 VEGF genes in Alzheimer's disease using single-nucleus RNA sequencing, finding altered expression and associations with disease endophenotypes.

bioRxiv · Apr 12, 2024 · PreprintNeuroscience

Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population

Michael C. Saul, ELIZABETH M. LITKOWSKI, Niran Hadad, Amy R. Dunn, Stephanie M. Boas, Jon A. L. Willcox, Julia E. Robbins, Yiyang Wu, Vivek M. Philip, Gennifer E. Merrihew, Jea Park, Philip L. De Jager, Dave Bridges, Vilas Menon, David Alan Bennett, , Catherine Cook Kaczorowski

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

bioRxiv · Jan 9, 2024 · PreprintNeuroscience

ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease

Anne Marie W. Bartosch, Elliot H. H. Youth, Shania Hansen, Yiyang Wu, Heather M. Buchanan, Maria E. Kaufman, Harrison Xiao, So Yeon Koo, Archana Ashok, Sharanya Sivakumar, Rajesh Kumar Soni, Logan C. Dumitrescu, Tiffany G. Lam, Ali S. Ropri, Annie Lee, , Andrew F. Teich

This study shows ZCCHC17 regulates RNA splicing in neurons and its dysfunction contributes to splicing abnormalities in Alzheimer's disease, with potential therapeutic implications.

Journal of Neuroscience · Nov 22, 2023Peer-reviewedNeuroscience

A longitudinal resource for population neuroscience of school-age children and adolescents in China

Xue-Ru Fan, Yinshan Wang, Da Chang, Ning Yang, Meng-Jie Rong, Zhe Zhang, Ye He, Xiao‐Hui Hou, Quan Zhou, Zhu-Qing Gong, Lizhi Cao, Hao-Ming Dong, Jing-Jing Nie, Li-Zhen Chen, Qing Zhang, , Yap Seng Chong

The paper introduces a longitudinal dataset of school-age children and adolescents in China, detailing its design, sampling, and neuroimaging measurements.

Scientific Data · Aug 21, 2023Peer-reviewedNeuroscience

Conserved cell-type specific signature of resilience to Alzheimer's disease nominates role for excitatory intratelencephalic cortical neurons

Maria A. Telpoukhovskaia, Niran Hadad, Brianna Gurdon, Yanchao Dai, Andrew R. Ouellette, Sarah M. Neuner, Amy R. Dunn, Jon A. L. Willcox, Yiyang Wu, Logan C. Dumitrescu, Orhan Bellur, Jigang Zhang, Kristen M. S. O’Connell, Eric B. Dammer, Nicholas T. Seyfried, , Catherine Cook Kaczorowski

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

bioRxiv · Apr 12, 2022 · PreprintNeuroscience