Wei‐Chen Cheng

The paper identifies SHLD2 loss as a vulnerability that enhances radiosensitisation when combined with Polθ inhibition in cancer cells.

The paper shows that inherited broken chromosomes in S. pombe undergo cycles of replication and processing, leading to chromosomal instability and rearrangements.

This paper introduces sigQC, an R package that standardizes gene signature quality control, demonstrating its application in evaluating signatures on cancer gene expression data.