Özlem Demir

This study generates the first wild-type full-length p53 tetramer model bound to DNA and analyzes its conformational dynamics and mutations in cancer mutants.

This study models the full-length APOBEC3B structure and finds that NTD-CTD interactions increase active site opening frequency.

This study identifies a novel allosteric pocket on APOBEC3B using computational methods but finds that metal contamination in screening samples led to false positive inhibitor results.