Bárbara de la Peña Avalos

This study shows that endogenous APOBEC3B causes DNA damage and replication stress, making cancer cells sensitive to CHK1 inhibitors.

This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.

This study models the full-length APOBEC3B structure and finds that NTD-CTD interactions increase active site opening frequency.