Dissecting the role of PCNA and Pif1 in replication of individual DNA molecules by DNA polymerase δ.
Manal S. Zaher, Carrie M. W. Stith, Ayush Mistry, Purna Bahadur Poudel, Edwin Antony, Peter Burgers, Roberto Galletto
This study uses single-molecule techniques to show PCNA, Pol δ, and Pif1 collaborate in DNA replication, with PCNA stabilization and diffusion reduction by both Pol δ and Pif1.
bioRxiv · May 21, 2026 · PreprintBiochemistry