Ayush Mistry

This study identifies a novel mechanism by which a bivalent E2:RING E3 complex facilitates E2 charging through competitive inhibition and accelerated release of charged E2.

This paper identifies two structural elements in HELB essential for its interaction with RPA-coated ssDNA, showing how they facilitate RPA displacement and DNA loop formation.

This study uses single-molecule techniques to show PCNA, Pol δ, and Pif1 collaborate in DNA replication, with PCNA stabilization and diffusion reduction by both Pol δ and Pif1.

This study identifies a feedback mechanism involving Cdk1/Wee1 signaling that primes and tunes RPA phosphorylation, crucial for cell cycle progression and DNA damage response.

This study reveals how Rad52 sorts and stacks Rad51 at DNA junctions to enhance homologous recombination by promoting Rad51 binding to RPA-coated ssDNA.