Rupesh Kumar Srivastava

Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma

This study identifies indole-3-lactic acid (ILA) as a gut-associated metabolite that revitalizes dysfunctional CD8⁺ T cells in osteosarcoma by enhancing their metabolic fitness and effector functions.

Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptation as a Conserved Mechanism of Immunotoxicity

This study identifies mitochondrial stress adaptation as a common mechanism of immunotoxicity across different nanoparticles and reveals particle-specific stress-response dynamics.

Vitamin D mitigates Inflammatory Bone Loss in Postmenopausal Osteoporosis via modulating the Gut-Immune-Bone axis

This study shows vitamin D prevents bone loss in postmenopausal osteoporosis by modulating the gut-immune-bone axis, resolving its paradoxical effects on osteoclasts.

Deoxycholic acid (DCA) alleviates LPS-induced Inflammatory Bone Loss via modulating the Gut-Bone homeostasis

This study shows that deoxycholic acid reduces LPS-induced inflammatory bone loss by improving gut microbiota balance and bone cell function.

ILC3 inhibits Osteoclastogenesis and ameliorates Inflammatory Bone Loss in Post-menopausal Osteoporosis

This study shows that ILC3 inhibits osteoclastogenesis and reduces inflammatory bone loss in post-menopausal osteoporosis by modulating ILC3 subsets and function.

Lactobacillus acidophilus ameliorates inflammatory bone loss under post-menopausal osteoporotic conditions via preventing the pathogenic conversion of gut resident pTregs into Th17 cells

Homeostatic balance of Gut-resident Tregs (GTregs) plays a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions

This study shows that gut-resident Tregs (GTregs) regulate bone health in post-menopausal osteoporosis by modulating osteoblast and osteoclast activity, with probiotics and SCFAs enhancing their effectiveness.