Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma
Leena Sapra, Asha Bhardwaj, Ankush Paladhi, Aasia Farhat, Taranjeet Kaur, Simran Preet Kaur, Chaman Saini, Venkatesan Sampath Kumar, Shah Alam Khan, Rupesh Kumar Srivastava
This study identifies indole-3-lactic acid (ILA) as a gut-associated metabolite that revitalizes dysfunctional CD8⁺ T cells in osteosarcoma by enhancing their metabolic fitness and effector functions.
bioRxiv · Aug 4, 2026 · PreprintImmunology