Leena Sapra

This study identifies indole-3-lactic acid (ILA) as a gut-associated metabolite that revitalizes dysfunctional CD8⁺ T cells in osteosarcoma by enhancing their metabolic fitness and effector functions.

This study shows vitamin D prevents bone loss in postmenopausal osteoporosis by modulating the gut-immune-bone axis, resolving its paradoxical effects on osteoclasts.

This study shows that ILC3 inhibits osteoclastogenesis and reduces inflammatory bone loss in post-menopausal osteoporosis by modulating ILC3 subsets and function.

This study shows that gut-resident Tregs (GTregs) regulate bone health in post-menopausal osteoporosis by modulating osteoblast and osteoclast activity, with probiotics and SCFAs enhancing their effectiveness.

This study identifies IL-9-producing Th9 cells as drivers of inflammatory bone loss in post-menopausal osteoporosis and shows that targeting IL-9 improves bone health in mice and humans.