Hyperosmotic stress induces rewiring of 3D chromatin interactions
John Patrick Flores, Andrea A. Perreault, Zachary Drum…·Douglas H. Phanstiel
One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.