Pavithran T. Ravindran

Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles

The paper shows that therapy-resistant cancer cell clones have distinct drug sensitivity profiles, and combinations targeting these subpopulations can effectively eliminate resistant populations.

Engineered Receptors for Soluble Cell-to-Cell Communication

This paper introduces SNIPR, a synthetic receptor that responds to soluble ligands, enabling targeted CAR T-cell therapy and synthetic cell signaling.

AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance

The paper shows melanoma cells develop therapy resistance through AP-1-mediated cellular memories that encode transient gene expression and chromatin changes.

A synthetic gene circuit for imaging-free detection of dynamic cell signaling

The paper introduces a synthetic gene circuit that detects dynamic cell signaling without requiring live-cell imaging, enabling the study of transient signaling events in fixed cells.

Engineering combinatorial and dynamic decoders using synthetic immediate-early genes

The paper constructs synthetic immediate-early genes (synIEGs) to study signal-decoding circuits, demonstrating their ability to implement complex regulation and respond to combined stimuli.