CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington's disease
Dahyun Yu, Nicole Zarate, Angel White, De’jah Coates, Wei Tsai, Carmen Nanclares, Francesco Cuccu, Johnny S. Yue, Taylor G. Brown, Rachel H. Mansky, Kevin Jiang, Hyuck Kim, Tessa Nichols‐Meade, Sarah N. Larson, Katherine Gundry, , Rocío Gómez‐Pastor
This study shows that reducing CK2 in HD mice improves neuroinflammation, HTT aggregation, and motor deficits by reducing synucleinopathy.
Acta Neuropathologica Communications · Jun 3, 2022Peer-reviewedNeuroscience