Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro E. Cruz, Yasmine T. Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd Eliot Golde, Paul John Whiting
The paper confirms that the PLCG2 P522R variant is protective against Alzheimer’s disease and shows it weakly activates PLCG2 enzyme function in microglia.
Alzheimer s Research & Therapy · Feb 2, 2019Peer-reviewedNeuroscience